May 27, 2025, 5:10 pm | Read time: 3 minutes

For a few months, it was relatively quiet around acting star Rosie O’Donnell, but now the 63-year-old is back—and how! The American actress appeared slimmer than ever and revealed how she has crafted her new self over the years.

Rosie O’Donnell Amazes Her Fans

On May 23, Rosie O’Donnell posted a photo on Instagram that bears little resemblance to the U.S. comedian’s earlier image. In the screenshot, where she shows herself on stage, she appears slim and trim. “I can’t believe this is me now,” she captioned the photo in amazement. She also added the hashtags “#mounjaro,” “#weightloss,” and “#bodydismorphia.” This clarifies what played a crucial role in her weight loss.

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How Mounjaro Works

In January 2023, Rosie O’Donnell revealed that she had been using the now-popular weight loss injection among U.S. celebrities, Mounjaro, since late 2022. The controversial medication, prescribed by a doctor to treat her Type 2 diabetes, reduces appetite and improves or accelerates the breakdown of fat and sugar in the body. The active ingredient is tirzepatide. Similar to Ozempic, Mounjaro also prolongs the feeling of fullness.

Also interesting: The “weight loss injection” Ozempic influences what users want to eat

Size L Instead of XXL – Effects of a New Lifestyle

In March of this year, Rosie O’Donnell provided an update on her life with Mounjaro via her TikTok account. “I’ve lost more weight. I take Mounjaro for my diabetes, and one of the side effects is weight loss,” she said. Additionally, after moving with her autistic son Clay from Los Angeles to Dublin in January, she no longer has a cook and now cooks for herself. This has also positively impacted her weight.

The effects in everyday life are noticeable. The Hollywood star has lost so much weight that her old clothes no longer fit. “I’ve always been someone with a weight problem. And now that I’m a size L—instead of XL or XXL—I find it shocking,” she shared in amazement.

Rosie O’Donnell Has Been Using the “Weight Loss Injection” for Three Years

Her weight loss journey with Mounjaro began about three years ago. Since then, she has also adjusted her diet. She mentioned that she consumes as little sugar and diet sodas as possible but drinks more water. “And I try to be more active. All these things together, that’s it,” she said on TikTok.

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Slimmer “Thanks” to Heart Attack

However, Rosie O’Donnell is not one of those celebrities who simply want to lose weight due to Hollywood’s obsession with thinness. No, the truth is a serious and long medical history. In 2012, at the age of 50, she suffered a severe heart attack due to her significant overweight, which nearly cost her life. “I should have died,” she revealed in an episode of “The Best Podcast Ever” in September 2023.

Doctors then urged her to lose about 44 pounds. She tried for a year, and success came in small steps. To speed things up, she underwent a necessary gastric bypass surgery in 2013. As a result, she lost an impressive 64 pounds within a year. “That surgery changed my life,” she told the U.S. magazine “People” nearly ten years ago.